Chromosome substitution strains
WebSep 8, 2012 · Chromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic … WebSep 29, 2024 · Analyzing metabolic traits and gene expression levels in the offspring of a series of crosses between mouse chromosome substitution strains demonstrated that inter-chromosomal epistasis was a dominant feature of these complex traits. Epistasis typically accounted for a larger proportion of the heritable effects than those due solely to …
Chromosome substitution strains
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WebJan 1, 2007 · By partitioning the genome into a panel of new inbred strains with single chromosome substitutions, one strain for each of the autosomes, the X and Y chromosome, and the mitochondria,... WebJul 8, 2003 · A chromosome substitution strain (CSS) is an inbred strain in which one chromosome has been substi-tuted from a different inbred strain by repeated backcrossing. A complete CSS set has one strain representing each chromosome against a uniform background, thus allowing genome-wide scans to be carried out for …
WebMay 23, 2024 · chromosome substitution The replacement of one or more chromosomes by others (totally or partially homologous) from another source (either a different strain … WebNov 4, 2024 · Chromosome substitution strains C57BL/6J-Chr# A /J/NaJ (20, 23), hereafter referred to as CSS, for all chromosomes except Y and the mitochondrial genome, were purchased from the Jackson Laboratory (JAX, Bar Harbor, Maine) and imported to the University of Colorado Boulder. The JAX strain IDs for the CSS are continuous from …
WebDec 1, 2003 · Chromosome substitution strains (CSSs) are important in this resource portfolio because of their demonstrated use for gene discovery, genetic and epigenetic studies, functional characterizations ... WebChromosome substitution strains QTL mapping can be accelerated using chromosome substitution strains (CSSs), which enable the first two steps above to be omitted. We propose replacing the name...
WebChromosome substitution strains QTL mapping can be accelerated using chromosome substitution strains (CSSs), which enable the first two steps above to be omitted. We …
WebChromosome substitution strains (CSSs) are a powerful complement to existing resources for studying multigenic traits. By partitioning the genome into a panel of … siding johnson city tnWebGenetic crosses and chromosome substitution experiments conclusively showed that the expression of both genes (located on the 2R chromosome) is repressed by factors on the third chromosome of the insecticide-susceptible 91C and rosy 506 strains. In contrast, the third chromosome of the MHIII-D23 and 91R strains carries a loss-of-function ... siding lethbridgeWebFeb 3, 2010 · Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-ChrA/J/NaJ panel of chromosome substitution strains (CSSs) is a unique model for studying resistance to diet-induced obesity. In the present study, three … siding joint flashingWebA chromosome substitution strain (CSS) or consomic strain is an inbred strain in which a single chromosome from a donor strain replaces the corresponding chromosome in the host/parental strain on a defined and uniform genetic background. From:Handbook of Behavioral Neuroscience, 2016 Related terms: Phenotype Mutation Quantitative Trait Locus siding layers on houseWebJan 23, 2024 · Chromosome substitution strains, also known as consomic strains, provide a simple model for exploring genetic influences. They consist of a panel of strains where one chromosome of a host strain is replaced by a homologous chromosome of a donor strain ( Matin et al., 1999; Singer et al., 2004; Ishii et al., 2011 ). siding kickout flashingWebDec 16, 2008 · Chromosome substitution strains (CSSs) enable statistically powerful studies based on testing engineered inbred strains that have single, unique, and … the politics of thatcherism stuart hallWebApr 16, 2004 · Chromosome substitution strains (CSSs) have been proposed as a simple and powerful way to identify quantitative trait loci (QTLs) affecting developmental, physiological, and behavioral processes. Here, we report the construction of a complete CSS panel for a vertebrate species. the politics of the english language