WebDec 15, 2012 · OSTI.GOV Journal Article: Cisplatin Pharmacokinetics in Nontumoral Pig Liver Treated With Intravenous or Transarterial Hepatic Chemoembolization Cisplatin Pharmacokinetics in Nontumoral Pig Liver Treated With Intravenous or Transarterial Hepatic Chemoembolization Full Record Related Research Abstract WebJan 1, 2009 · We evaluated the toxicity and pharmacokinetics (PK) of higher pemetrexed doses with cisplatin and vitamin supplementation. Experimental design: Folic acid and vitamin B(12) were administered per label recommendations. Results: The maximum tolerated dose was 900 mg/m(2) pemetrexed + 75 mg/m(2) cisplatin.
Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells
WebCisplatin, a commonly used chemotherapeutic agent, is nephrotoxic. The mechanism by which cisplatin selectively kills the proximal tubule cells was heretofore unknown. WebPurpose: Cisplatin and carboplatin are frequently used drugs in the treatment of pediatric hepatoblastoma. Dosing guidelines for these drugs in children requiring peritoneal dialysis are lacking. Here, we describe the case of a 3-year-old boy with pre-existing end-stage renal disease on peritoneal dialysis, requiring treatment with cisplatin and carboplatin for … imagine kona coffee beans
Chapter 12: Pharmacokinetics of Chemotherapeutic Agents in …
WebDec 31, 2008 · The cisplatin dose was 75 mg/m 2 for all cohorts and the pemetrexed dose was increased in increments of 100 mg/m 2 for subsequent cohorts. Treatment and dose escalation scheme. Pemetrexed and cisplatin were administered on day 1 of a 21-d cycle as i.v. infusions of 10 and 60 min, respectively. WebOct 7, 2024 · In addition, significant immune cell infiltration was observed in the kidney after four doses of 9 mg/kg cisplatin, contrary to what has been previously reported. These … WebCISPLATIN Although they are members of the same chemical family, cis- platin is considered to be superior therapy for specifictumor … list of fh