Mouse klotho protein

Author: cohc

August undefined, 2024

Nettet27. aug. 2024 · Klotho has been recognized as a gene involved in the aging process in mammals for over 30 years, where it regulates phosphate homeostasis and the activity of members of the fibroblast growth factor (FGF) family. The α-Klotho protein is the receptor for Fibroblast Growth Factor-23 (FGF23), regulating phosphate homeostasis and … NettetGene Expression + Phenotype. Homozygous mutant mice have a short lifespan and growth retardation with one allele homeostatic imbalances and soft tissue calcification …

Recombinant α-Klotho Protein Alleviated Acute Cardiorenal

NettetMouse myeloma cell line, NS0-derived mouse Klotho beta protein Phe53-Leu995, with a C-terminal 10-His tag Purity >90%, by SDS-PAGE visualized with Silver Staining and … Nettet7. feb. 2024 · Background: Calcific aortic valve disease (CAVD) is a chronic inflammatory disease. Soluble extracellular matrix (ECM) proteins can act as damage-associated … ps5 controller am pc forza

Recombinant Human Klotho beta Protein, CF 5889-KB-050: …

Nettet13. jan. 2024 · Klotho is an age-extending, cognition-enhancing protein found to be down-regulated in aged mammals when age-related diseases start to appear. Low levels of … Nettet7. feb. 2024 · Background: Calcific aortic valve disease (CAVD) is a chronic inflammatory disease. Soluble extracellular matrix (ECM) proteins can act as damage-associated molecular patterns and may induce valvular inflammation. Matrilin-2 is an ECM protein and has been found to elevate the pro-osteogenic activity in human aortic valve … NettetThe aging suppressor gene Klotho encodes a single-pass transmembrane protein. Klotho-deficient mice exhibit a variety of aging-like phenotypes, many of which are similar to those observed in fibroblast growth factor-23 (FGF23)-deficient mice. To test the possibility that Klotho and FGF23 may function in a common signal transduction … horse mounts donkey

KL Gene - GeneCards KLOT Protein KLOT Antibody

Klotho protein in neurodegenerative disorders SpringerLink

NettetKlotho-deficient mice show severe hyperphosphatemia and ectopic calcification of soft tissues due to excess vitamin D (2, 7). Both Klotho and Klotho-beta are cofactors for … NettetKlotho protein is a β-glucuronidase capable of hydrolyzing steroid β-glucuronides. Two molecules are produced by the Klotho gene, a membrane bound form and a circulating … ps5 control on pcNettet9. apr. 2024 · Klotho is an anti-ageing protein that can attenuate ageing-related diseases to extend healthspan. 8, 9 α-Klotho declines with ageing in mice and humans. 10 … horse mounts female cow

"Nettet11. jun. 2024 · Klotho is a natural protein enzyme that exists within the body and brain. This protein is created by the KL gene and is produced in the kidneys. It appears to have a large role in the regulation of phosphate, but this is only a small portion of the significance of Klotho. " - Mouse klotho protein

Mouse klotho protein

Recombinant Mouse Klotho (aa 35-982) Protein, CF

NettetChinese Hamster Ovary cell line, CHO-derived mouse Klotho protein Ala35-Lys982, with a C-terminal 6-His tag. Accession # O35082.2. N-terminal Sequence Analysis. Ala35. … Nettet26291 56636 Ensembl ENSG00000105550 ENSMUSG00000030827 UniProt Q9NSA1 Q9JJN1 RefSeq (mRNA) NM_019113 NM_020013 RefSeq (protein) NP_061986 NP_064397 Location (UCSC) Chr 19: 48.76 – 48.76 Mb Chr 7: 45.26 – 45.26 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibroblast growth factor 21 is a …

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Nettet30. jul. 2024 · Both in mice and humans, the Klotho gene is located on chromosome 13q12; it encompasses 50 kb and consists of 5 exons. As in the mouse gene, in the … Nettet22. feb. 2024 · αKlotho (hereafter referred to as Klotho) is a type I membrane-bound protein mainly expressed in renal tubules, parathyroid cells, choroid plexus, and sinoatrial node 1,2,3.Klotho knockout mice ...

NettetThe Klotho proteins, Klotho and Klotho beta (beta KL), are type I transmembrane glycoproteins with extracellular regions that contain two beta-glycosidase-like repeats. … Nettet12. jan. 2024 · Klotho is an anti-aging, single-pass transmembrane protein found mainly in the kidney. Although aging is likely to be associated with DNA damage, the involvement of Klotho in protecting cells from DNA damage is still unclear. In this study, we examined DNA damage in human kidney cells and mouse kidney tissue after ionizing radiation (IR).

NettetExpression of Klotho, a protein of age-related declines, was upregulated by parishin in serum and vascular tissue in naturally aged mice. Furthermore, FoxO1, on Klotho/FoxO1 signalling pathway, was increased in the parishin-intervened group, accompanied by the downregulated phosphorylated FoxO1. Taken together, parishin can increase Klotho ... Nettet22. mar. 2024 · Heart disease is the leading cause of death worldwide. The major cause of heart failure is the death of the myocardium caused by myocardial infarction, …

Nettet9. nov. 2024 · Klotho depletion in the CP caused by aging or experimental manipulation. (A) CP (arrow) in the lateral ventricle of a 4-mo-old WT mouse visualized by klotho immunostaining of a coronal brain section.(B) Images of confocal optical sections of CPs in the lateral ventricles of 4-mo-old WT and kl/kl mice immunostained for klotho (green) …

Nettet6. nov. 1997 · A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, ... Kyte–Doolittle hydrophobicity analysis of mouse KL protein (GeneWorks ver2.5 ... ps5 controller am handyNettet6. nov. 1997 · A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin … ps5 controller an pc anschließenNettet12. mar. 2024 · Senescent cells cause reduced α-Klotho, partially due to their production of activin A and IL-1α. Targeting senescent cells boosts α-Klotho in mice and humans. Thus, clearing senescent cells restores α-Klotho, potentially opening a novel, translationally-feasible avenue for developing orally-active small molecule, α-Klotho … ps5 controller am pc fortniteNettetObjective: Soluble serum Klotho is a new biomarker linked to chronic kidney disease, cardiovascular disease and diabetes. This study describes the evaluation and comparison of two different immunoassays and establishment of assay specific reference intervals in … ps5 controller asymmetricalNettet19. jan. 2012 · Klotho is a recently discovered anti-aging gene. The purpose of this study was to investigate whether klotho gene transfer attenuates superoxide production and oxidative stress in rat aorta smooth muscle (RASM) cells. RASM cells were transfected with AAV plasmids carrying mouse klotho full-length cDNA (mKL) or LacZ as a control. ps5 controller angebotNettetWe report here the identification of mouse betaklotho (betakl), which encodes a type I membrane protein with high resemblance to Klotho (KL). Both betaKL and KL consist … horse mounts humanNettetKl þ /À mice had lower levels of Klotho protein in the plasma, kidney, and urine at baseline, which became undetectable after AKI (Figure 4 a-d). ps5 controller an der switch